1 edition of Theophylline therapy update found in the catalog.
Theophylline therapy update
Includes bibliographical references.
|Statement||edited by Stuart M. MacLeod and Alan Isles.|
|Contributions||Isles, A. F., MacLeod, Stuart M., Astra Pharmaceuticals Canada.|
|LC Classifications||RM666.T39 T46 1982|
|The Physical Object|
|Pagination||90 p. :|
|Number of Pages||90|
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AMERICAS FIRST MARINES
Theophylline is a methylxanthine compound that is used for the treatment of asthma, chronic obstructive pulmonary disease (COPD; chronic bronchitis and emphysema), and premature bronchodilatory effects of theophylline are useful primarily for patients with asthma because bronchospasm is a key component of that disease state.
1 The use of theophylline in patients with. In the chronic management of asthma or chronic obstructive pulmonary disease patients, theophylline is now considered to be adjunctive therapy. 5,6,7, and 8 Asthma is now recognized as an inflammatory disease, and inhaled corticosteroids are considered the mainstay of therapy.
5,7 Inhaled selective β 2-agonists are used as bronchodilators in asthmatic Theophylline therapy update book. Theophylline (dimethylxanthine) has been used to treat airway diseases for more than 80 years.
It was originally used as a bronchodilator, but the relatively high doses required are associated with frequent side effects, so its use declined as inhaled β 2-agonists became more widely recently it has been shown to have antiinflammatory effects in asthma and chronic obstructive.
Leslie Hendeles, Miles Weinberger, Avoidance of Adverse Effects during Chronic Therapy with Theophylline, Drug Intelligence & Clinical Pharmacy, /, 14,Cited by: Among elderly patients receiving therapy with theophylline, eligible case patients hospitalized for theophylline toxicity and matched controls were identified.
The Global Initiative for Asthma Guidelines guidelines for asthma recommend that theophylline can be used as an add-on therapy to patients not controlled by low doses of inhaled corticosteroids but recommend long-acting β 2-agonists as more effective and with fewer adverse effects ().Several clinical studies Theophylline therapy update book demonstrated that adding theophylline to inhaled corticosteroids in.
Initiation of Theophylline therapy at a low dose with subsequent slow titration to a predetermined age-related maximum dose will significantly reduce the frequency of these transient adverse effects (see DOSAGE AND ADMINISTRATION, Table V).
In a small percentage of patients. INTRODUCTION. Theophylline was first identified as having potential for asthma as a bronchodilator in and , but general use as a bronchodilator was not seen until the combination of theophylline and ephedrine was described in a publication .Such preparations, often with a mild sedative added, dominated the market for oral theophylline products until.
During oral theophylline treatment, the mean (SEM) serum theophylline level at the time of maximum improvement for these 10 patients was () mg/L (to convert to micromoles per liter, multiply by ).
During intranasal theophylline treatment, the mean serum theophylline level was (). Theophylline is best absorbed by the body orally and it is rapidly distributed to the body. Side effects that may be experienced by taking theophylline include chest pain, seizures, arrhythmia, vomiting that is persistent, lightheadedness or fainting spells and shaking or tremors.
ORIGINAL CONTRIBUTION theophylline, prediction of levels Prediction of Serum Theophylline Levels Because theophyl]ine (T) has a narrow therapeutic index, serum concentra- tions resulting from previous outpatient therapy must be considered when planning intravenous (IV) aminophylline dosage in the emergency depart- ment (ED).
Sustained-release theophylline is a mild to moderate bronchodilator used as an alternative, although not preferred, adjunctive therapy with inhaled corticosteroids. Theophylline may have mild anti.
It is ironic that many of the drugs used to treat COPD have been known since antiquity, yet we are still struggling to understand their basic mechanisms and how to use them. Theophylline is the best example of this Theophylline therapy update book, although anticholinergic agents and β-agonists share this irony.
Methylxanthines have been used for centuries to treat obstructive lung disease, but in the last 20 years. The molecular formula of anhydrous theophylline is C 7 H 8 N 4 O 2 with a molecular weight of Theophylline Oral Solution USP is available as a liquid intended for oral administration, containing 80 mg of theophylline anhydrous.
Current guidelines suggest theophylline as an alternative to ICSs in children with mild persistent asthma and as an add-on therapy with a low-dose ICS in children with moderate-to-severe asthma. Patients may experience deterioration of asthma control following withdrawal of theophylline.
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Serum Theophylline Concentration Monitoring The serum theophylline concentration should be measured immediately upon presentation, hours later, and then at sufficient intervals, e.g., every 4 hours, to guide treatment decisions and to assess the effectiveness of therapy.
Serum theophylline concentrations may continue to increase after. This study indicated that, in asthmatic patients previously receiving twice-daily theophylline therapy, switching to a daily single dose of Uniphyl maintained stable blood levels with a very low incidence of side effects and a modest improvement to FEV1 at the time of the normal serum peak of theophylline.
This study suggests that Uniphyl can. theophylline each year in the United States alone, and the actual number might run into the tens of thousands.
Drs. Lam and Newhouse point out that numerous alternatives to theophylline now exist, and in most clinical settings a well-designed regimen of inhaled drugs provides superior therapy with a high degree of safety.
The transient caffeine-like adverse reactions occur in about 50% of patients when theophylline therapy is initiated at doses higher than recommended initial doses (e.g., > mg/day in adults and >12 mg/kg/day in children beyond >1 year of age).
During the initiation of theophylline therapy, caffeine-like adverse effects may transiently alter. Theophylline is an oral medication used to treat asthma and other lung diseases.
Learn who it’s for, how it works, its side effects, warnings, and more. Purchase Asthma - 3rd Edition. Print Book & E-Book.
ISBN Theophylline is usually taken twice a day, although some doctors may prescribe just one dose a day. Take the tablets/capsules exactly as your doctor tells you to. For twice daily doses, always try to take your doses 12 hours apart and at the same times each day.
For. Precautions. Drug information provided by: IBM Micromedex It is very important that your doctor check the progress of you or your child at regular visits, especially for. Theophylline in the past and present. Theophylline is a drug that has been in use for asthma since the 's.
Structurally related to caffeine, it was first isolated from tea leaves in the late. Theophylline comes as an extended-release (long-acting) tablet, extended-release capsule, and a solution (liquid) to take by mouth.
It usually is taken every 6, 8, 12, or 24 hours. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand.
Discontinue theophylline for at least 24 hours prior to this type of stress testing. Maintenance theophylline therapy and other xanthine derivatives may abolish the coronary vasodilatation induced by dipyridamole administration via antagonism of adenosine.
Theophylline is derived from methylxanthine, naturally present in tea and cocoa beans. Initially used medically in as a diuretic, theophylline was one of the first drugs for asthma and COPD/emphysema (beginning in ), after its bronchodilation effects were discovered.
Theophylline also has cardiac and central nervous system stimulant side effects and can produce tachyarrhythmias. The transient caffeine-like adverse reactions occur in about 50%of patients when theophylline therapy is initiated at doses higher than recommended initial doses (e.g., > mg/day in adults and > 12 mg/kg/day in children beyond 1 year of age).
During the initiation of theophylline therapy, caffeine-like adverse effects may transiently alter. Free E-newsletter Subscribe to Housecall. Our general interest e-newsletter keeps you up to date on a wide variety of health topics.
Sign up now. Uses. Theophylline is used to treat lung diseases such as asthma and COPD (bronchitis, emphysema).It must be used regularly to prevent wheezing and shortness of breath. This medication belongs to. Nuelin SR theophylline mg tablet bottle - white, round biconvex tablets marked N/L Nuelin SR theophylline mg tablet bottle - white round biconvex tablet N/L on one side and on the other.
Nuelin Syrup theophylline mg/5 mL bottle - clear liquid, berry flavour. 5 Pharmacological Properties. Pharmacodynamic Properties. Fisher J, Graudins A. Intermittent haemodialysis and sustained low-efficiency dialysis (SLED) for acute theophylline toxicity. J Med Toxicol.
Sep. 11 (3) Hopkins ME, MacKenzie-Ross RV. Case Report: The risks associated with chronic theophylline therapy and measures designed to improve monitoring and management. Theophylline (3-methyxanthine) has been used to treat airway diseases for over 70 years.
It was originally used as a bronchodilator but the relatively high doses required are associated with frequent side effects, so its use declined as inhaled β2-agonists became more widely used.
More recently it has been shown to have anti-inflammatory effects in asthma and COPD at lower concentrations. Theophylline is a bronchodilator that belongs to a class of drugs called methylxanthines used in the treatment of respiratory diseases such as chronic obstructive pulmonary disease (COPD) and asthma.
Bronchodilators are the main form of therapy for. The document also recognizes the benefits of the early use of combination therapy with a long-acting beta-agonist and inhaled corticosteroid as opposed to increasing the dose of inhaled corticosteroids.
Use of leukotriene receptor antagonists and theophylline therapy as adjunct therapies is also discussed. Theophylline, also known as 1,3-dimethylxanthine, is a phosphodiesterase inhibiting drug used in therapy for respiratory diseases such as chronic obstructive pulmonary disease (COPD) and asthma under a variety of brand names.
As a member of the xanthine family, it bears structural and pharmacological similarity to theobromine and caffeine, and is readily found in nature, being present in. This will be a prospective randomized double-blinded parallel group clinical trial evaluating the short-term effects of theophylline therapy on exercise duration and lung function in patients with chronic obstructive pulmonary disease already receiving both tiotropium and a long-acting beta-agonist (salmeterol or formoterol).
TERMS AND CONDITIONS. GOVERNING USE OF WEBSITE AND MATERIALS. The following terms and conditions are an agreement (the “ Agreement ”) governing your access and use of the [Pediatric Care Online (PCO)] website (the “ Website ”) and its content (collectively, the “ Materials ”).
Please read these terms carefully. In patients with theophylline overdose who are at high risk for theophylline-induced seizures, e.g., patients with acute overdoses and serum theophylline concentrations > mcg/mL or chronic overdosage in patients > 60 years of age with serum theophylline concentrations > 30 mcg/mL, the need for anticonvulsant therapy should be anticipated.
Theophylline toxicity is most likely to occur when serum concentration is: A. A. mcg/mL. B. B. ˃ 20 mcg/mL. C. C. mcg/mL. D. D. Theophylline toxicity does not occur Answer: B. Theophylline toxicity occurs when serum concentration exceeds 20 mcg/mL 4.Chronoptimized theophylline therapy once-daily dosing in the evening versus conventional twice-daily dosing.
Am Rev Respir Dis –90 PubMed CrossRef Google Scholar De Backer W, Vos W, Van Holsbeke C, Vinchurkar S, Claes R, Hufkens A, Parizel PM, Bedert L, De Backer J () The effect of roflumilast in addition to LABA/LAMA/ICS treatment.
Theophylline is a non-selective PDE inhibitor that is generically available and has a long history of use in pediatric patients, making it an ideal drug for re-purposing in youth with PHP.
Furthermore, the pharmacokinetics of theophylline are well understood and serum drug levels are .